اصطناع و توصيف عدة مشتقات للكركمين و دراسة فعاليتها الحيوية

Abstract EN

As a result of the emergence of many cases of bacterial resistance to antibiotics available in the pharmaceutical market, it was necessary to search for other new antibiotics that cover this aspect, and within this framework, in order to prepare compounds that may be effective against these germs and protect human life from these stubborn germs.

In this study six derivatives of curcumin were synthesized, and these compounds are : 5-diphenylpenta-1-4-dien-3-one.

1, 1, 9-diphenyl-1, 3, 6, 8-nonatetraen-5-one.

1, 5-(dimethylamino phenyl)-1, 4- pentadien-3-one.

1,5- (2-hydroxyphenyl) -1, 4- pentadien-3-one.

1, 5-(4-methoxyphenyl)-1, 4- pentadien-3-one.

1, 9- diphenyl-1, 3, 6, 8-nonatetraen-5-hydrazone.

The prepared compounds were characterized by IR, LC-MS, HPLC and ¹H-NMR spectra.

The importance of these compounds due to their biological activity, all compounds were screened for their antibacterial activity against gram positive : Staphylococcus Epidermises at 500, 1000, 5000, 10000 ppm, the results were compared with standard antibiotics (Gentamicin, Tobramycin, Neomycin), all compounds showed good activity, and the compound IV which have two hydroxyl groups showed the highest antibacterial activity, compared with other derivatives.