عزل و استخلاص فيتامين C من نبات فاكهة التنين : دراسة بعض المتغيرات الكيموحيوية على الجرذان المختبرية

Abstract EN

The research included knowledge of the protective effect of the aqueous extract of the dragon fruit plant (hylocereous undates) and the active compounds isolated from it (vitamin C) in reducing the effect of RA induced by (CFA) (Freund's Complete Adjuvant) by studying some changes in histological and biochemical parameters.

The animals used in the experiment were divided into 4 groups as follows : the first group (negative control group) was dosed with plain water orally only, the second group was given RA (positive control group), the third group was dosed with aqueous extract of dragon fruit (250 kg/mg), and the fourth group was dosed with vitamin C isolated from dragon fruit (kg/mg 200).

The results showed a significant increase in the rats treated with CFA for each of (WBC, Globulin, Hey, Anti-ccp) and a significant decrease in (Gpx, GSH) compared with the negative control group, while the results showed a significant decrease in the groups treated with aqueous extract for each of (WBC, Hey, Anti ccp, Globulin) and showed a significant increase in (Gpx, GSH) compared with the positive control group, while the results showed a significant increase in the groups treated with vitamin C for each of (Gpx, GSH) and a significant decrease in (WBC, Hey, Anti-ccp, Globulin).

It is concluded from the study that the aqueous extract and (vitamin C) showed a protective effect that reduced the damage caused by RA by (CFA) and improved the joint tissue, as shown by the histological sections.