دراسة وتشخيص الجسيمات النانوية فائقة المغناطيسية المغلفة ببوليمر الكايتوسان (SPIONs-CS)‎

Abstract EN

The nanoparticles of supermagnetic iron oxide uncoated (SPIONs) and coated with polymer chitosan (SPIONs-CS) were studied and characterized, taking into account the importance of these materials in different fields of biochemical and biomedical applications due to their distinctive chemical and physical properties.

Uncoated iron oxide nanoparticles (SPIONs) and polymer chitosan-coated (SPIONs-CS) using the co-precipitation method as the most widely used chemical method for preparing these particles for biological applications.

And Fe2+ in an aqueous solution using sodium citrate as a surfactant inside a closed system, the packaging method was used during the preparation In situ method, the size and stability of magnetite nanoparticles Fe3O4 (Magnetite) are precisely controlled using different chemical and physical parameters in order to obtain iron oxide particles SPIONs-CS have small particle size and distribution suitable for medical and biological applications.

The SPIONs-CS were examined using different techniques.

The results of XRD tests showed the presence of peaks corresponding to the magnetic iron phase and that the chitosan polymer shell did not affect the crystalline phase of magnetite Fe3O4.

It was found from the results of the transmission electron microscope (TEM) technique that the nanoparticles were within the nanoscale range of 20 nm, which is close to the size obtained from XRD technique, which was 22.8 nm.

Negative and with a zeta voltage of -28.4 mv at a chitosan concentration of 0.125g CS.

The results of the SEM analysis were that the particles are spherical in shape and spaced according to the CS chitosan concentrations used for encapsulation with an average diameter of 20.023nm (27.58nm, 35.127nm) for three concentrations used for encapsulation (0.100g, 0.125g, 0.150g), respectively.

The iron oxide particles showed a superior magnetic behavior according to the magnetometer technology of the vibration sample VSM, where the results showed that the size of the resulting particles depends largely on the stirring rate and on the concentration of sodium hydroxide and depends on the concentrations of the CS chitosan polymer used for packaging.