صياغة مضغوطات قابلة للتفتت في الفم لمادة بيروكسيكام بالمشاركة مع مادة كودئين فوسفات وتقييمها في الزجاج

Abstract EN

Administration of drugs through the oral mucosa has important advantages compared to the delivery of drugs through the mouth, the most important advantage is the avoidance of the first hepatic passage in addition to the speed of onset of action.

This research aims to formulate orally disintegrating tablets of Piroxicam in combination with codeine phosphate in order to increase their release from the pharmaceutical dosage form.

The compatibility of the two pharmaceutical substances was studied by conducting a thermally equal stress study and using techniques such as DSC and FTIR before the formulation.

After that, nine different pharmaceutical formulas were prepared and differed in super-disintegrant and concentration.

The results of the DSC and FTIR tests showed that there was a solid-solid interaction between Piroxicam and codeine phosphate, and that the drug content of the two drugs was within constitutional limits as a result of the thermally equal stress test.

The formula F3 which contains crosspovidone-XL as a super-disintegrating agent with a concentration of 7.5% has the lowest disintegration time.

The release rate of codeine phosphate and piroxicam in the selected prepared formulations F3, F6 and F7 was high, 80% of codeine phosphate and piroxicam were released during the first four minutes of the dissolution test.