تحضير أفلام عينية للبريمونيدين طرطرات وتقييمها في الزجاج

Abstract EN

Pharmacological treatments of glaucoma are based on drugs that reduce intraocular pressure, to keep it within its normal values, as high eye pressure is an important cause of exacerbation of the condition.

Modified release forms are of interest in this field, including Ophthalmic films, that improves patient compliance by comparison with multi-dose eye drops.

Brimonidine tartrate is an α2-receptor agonist, and it’s effective in the treatment of glaucoma.

The aim of this study was to prepare ophthalmic films of Brimonidine Tartrate to increase the quality of glaucoma treatment.

Films were prepared by solvent casting technique by using HPMC k15m and PVPk30 in different ratios, and PEG 400 was used as a plasticizer.

Physicochemical properties of films and drug release studies by a Franz cell were done.

It was concluded that formula A6 has a prolonged release time comparing to the other prepared formulas.