تأثير الميكوبين المستخمص من الطماطم عمى الإنزيمات المضادة للأكسدة في الجرذان

Abstract EN

The aim of this study was the extraction of lycopene from local tomatoes cultivated in Saudi Arabia and the evaluation of its effect in antioxidative enzymes.

Forty eight (24 males and 24 females) Wister albino rats (100 ± 10 g) were used in this study.

Different orally administered lycopene, extracted from tomatoes, at doses (0.5, 1.0 and 1.5 g/kg body weight/day) for eight weeks were given to rats.

Results of the study showed positive and strong correlation between lycopene and the activity of serum catalase enzyme (CAT) of rats (r2=0.819 and 0.784 for males and females, respectively).

The highest dose of lycopene for females and the doses of 1.0 and 1.5 g lycopene/kg BW for males increased significantly CAT activity in serum compared to the control group.

CAT activity significantly increased in males than females at dose of 1.0 g lycopene/kg BW.

Activity of plasma glutathione peroxidase (GSH-Px) of rats followed the same trend in both sexes at the highest dose of lycopene.

However, gender had no effect in the activity of this enzyme.

Correlation between GSH-Px and lycopene was positive but intermediate (r2=0.615 and 0.585 for males and females, respectively).

Despite the increase in super oxides dismutase (SOD) activity in serum of males at the highest dose of lycopene compared to the control group, and its higher activity in the serum of males than females, the correlation between lycopene and SOD was weak (r2=0.239 and 0.286 for males and females, respectively).

The results of this study demonstrated the role of lycopene in the reduction of oxidative stress through its role in the activation of antioxidative enzymes.