التغيرات الدقيقة المستحدثة بجرعة منفردة من الكادميوم في كبد و كلى الفئران

Abstract EN

This study was conducted to investigate the ultrastructural changes in the liver and kidney of mice induced by a single dose of Cadmium chloride.

A group of mice (25) were injected with a single intraperitoneal dose of Cadmium chloride (2 mg/ kg) body weight.

After 4 weeks, all treated and untreated animals were killed, the live and kidney were removed and processed for transmission electron microscopy.

Ultrastructure of liver tissues showed increase in the number of lysosomal structure and oil droplets.

Also changes in the mitochondrial structures and enlarge in Kupffer cells were observed.

Ultrastructure of kidney tubule cells showed cellular necrosis, disappearing of microvilli and changes in the mitochondria and nucleus.

Basing upon the results of electron microscopy investigation, it was possible to conclude that a single PI dose of cadmium chloride (2mg/kg) can induce ultrastructural changes in both liver and kidney tissues.