The effect of lidocaine and magnesium sulfate on prevention of ventricular fibrillation in coronary artery bypass grafting surgery
Joint Authors
Janati, M.
Vaziri, M. T. Moeen
Jouibar, R.
Akhlagh, S. H. A.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 12, Issue 3 (31 May. 2010), pp.298-301, 4 p.
Publisher
Publication Date
2010-05-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : one of the most common events, after the release of aortic cross-clamp in patients undergoing coronary artery bypass grafting surgery is reperfusion induced ventricular fibrillation, which occurs in 74 % of 96 % of patients.
Regarding the controversies over the use of lidocaine or magnesium sulfate for the prevention of ventricular fibrillation following the release of aortic cross-clamp, this study was designed to compare the effectiveness of magnesium sulfate and lidocaine to suppress ventricular fibrillation.
Methods : in a double blind, prospective, randomized, controlled trial study, 76 patients who were candidates for elective coronary artery bypass grafting surgery were divided into three groups including Group A (lidocaine, n = 26), group B (magnesium sulfate, n = 25), and group C (normal saline, n = 26).
Lidocaine (1.5 mg / Kg), magnesium sulfate (30 mg / Kg) and normal saline were administered 5 minutes before the release of aortic cross clamp.
Results : the incidence of ventricular fibrillation significantly decreased in patients receiving magnesium sulfate (12 % vs.
26.9 % and 44 % in patients who received lidocaine and normal saline, respectively) There was no statistically significant difference between the groups with respect to age, ejection fraction (L / min), anesthetic time (min), cross-clamping time (min), PH, HCT (%), and serum K + level (meq).
Conclusion : the administration of lidocaine and magnesium sulfate before the release of aortic cross-clamp reduces the incidence of postoperative ventricular fibrillation in adult patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass.
In our study, magnesium sulfate was more efficient in prevention of ventricular fibrillation than lidocaine.
Administration of magnesium sulfate (30 mg / kg) caused no toxic effect and was safe for patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass.
American Psychological Association (APA)
Vaziri, M. T. Moeen& Jouibar, R.& Akhlagh, S. H. A.& Janati, M.. 2010. The effect of lidocaine and magnesium sulfate on prevention of ventricular fibrillation in coronary artery bypass grafting surgery. Iranian Red Crescent Medical Journal،Vol. 12, no. 3, pp.298-301.
https://search.emarefa.net/detail/BIM-252862
Modern Language Association (MLA)
Akhlagh, S. H. A.…[et al.]. The effect of lidocaine and magnesium sulfate on prevention of ventricular fibrillation in coronary artery bypass grafting surgery. Iranian Red Crescent Medical Journal Vol. 12, no. 3 (May. 2010), pp.298-301.
https://search.emarefa.net/detail/BIM-252862
American Medical Association (AMA)
Vaziri, M. T. Moeen& Jouibar, R.& Akhlagh, S. H. A.& Janati, M.. The effect of lidocaine and magnesium sulfate on prevention of ventricular fibrillation in coronary artery bypass grafting surgery. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 3, pp.298-301.
https://search.emarefa.net/detail/BIM-252862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 301
Record ID
BIM-252862