تحوير كيميائي جديد للمضاد الحيوي الارثرومايسين و دراسة فعاليته البايولوجية ضد الجراثيم المرضية السالبة و الموجبة لملون كرام

Abstract EN

In this study a new erythromycin derivative has been prepared for erythromycin (antibiotic) by introducing a tosyl group instead of the proton which attached to the oxygen atom ( proton replacement ) .

This modification help us to obtain derivative with high biological activity against Gram positive and Gram negative bacteria .

The product is more highly crystalline and higher melting point (MP) by comparison with starting material ( erythromycin ).It was noted that the product has substituted a tosyl group at position -OH as indicated by ultraviolet( UV) and infrared ( IR) spectroscopy identifications .

Also the study was determined the antibacterial activity properties of the product , represented by inhibition diameters, minimum inhibitor concentration (MIC), and median lethal dose ( LD50).