Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran
Joint Authors
Karimi, M.
Afrasiabi, A. R.
Dehghani, S. J.
Dashtrazhen, A. Amiri
Nasirabadi, Sh.
Dehbozorgian, J.
Murshedi, N.
Imanifard, Sh.
Mehrpoor, Sh.
Gerdabi, Sh.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 13, Issue 8 (31 Aug. 2011), pp.586-589, 4 p.
Publisher
Publication Date
2011-08-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
We report a 23-year-old man and three members of his family with Hb J-Iran confirmed by electrophoresis, chain separation by high performance liquid chromatography and sequencing.
Alpha thalassemia was also confirmed in two family members.
The substitution at β77 led to a higher negative charge of the βJ-Iran subunit, which enhanced its electrostatic attraction for the normal positively-charged α subunit.
Therefore, more Hb J-Iran than Hb A forms in the red blood cells of heterozygotes.
In α-thalassemia, the more attractive βJ-Iran subunit out-competes βA subunits in forming assemblies with deficient α subunits, so even more Hb J-Iran was formed.
American Psychological Association (APA)
Dehghani, S. J.& Dashtrazhen, A. Amiri& Nasirabadi, Sh.& Dehbozorgian, J.& Afrasiabi, A. R.& Karimi, M.…[et al.]. 2011. Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran. Iranian Red Crescent Medical Journal،Vol. 13, no. 8, pp.586-589.
https://search.emarefa.net/detail/BIM-268097
Modern Language Association (MLA)
Karimi, M.…[et al.]. Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran. Iranian Red Crescent Medical Journal Vol. 13, no. 8 (Aug. 2011), pp.586-589.
https://search.emarefa.net/detail/BIM-268097
American Medical Association (AMA)
Dehghani, S. J.& Dashtrazhen, A. Amiri& Nasirabadi, Sh.& Dehbozorgian, J.& Afrasiabi, A. R.& Karimi, M.…[et al.]. Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 8, pp.586-589.
https://search.emarefa.net/detail/BIM-268097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 589
Record ID
BIM-268097