The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population
Joint Authors
Khorshid, H. R. Khorram
Gozalpour, E.
Kamali, K.
Ohadi, M.
Karimlu, M.
Shahhusayni, M. H.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 13, Issue 4 (30 Apr. 2011), pp.256-262, 7 p.
Publisher
Publication Date
2011-04-30
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: Apo lipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain.
ATP-binding cassette transporter A1 (ABCA1) gene on chromosome 9, which has been known by genome-wide AD linkage study, has an important role in cellular cholesterol efflux.
This study determines the association between sporadic AD and the human ABCA1 and APOE gene polymorphisms in Iranian population.
Methods : 154 AD cases and 162 control subjects from Iranian population were genotyped for APOE genotypes and ABCA1 polymorphism (R219K).
Results : the frequency of ε2ε3 genotype was higher in control subjects comparing AD patients but was not significant (13% versus 5.8%) and ε3ε4 genotype frequency was significantly higher in AD cases comparing with control subjects.
APOE-ε2 allele frequency in cases was lower than control subjects but this difference was not significant (4.5% versus 8%).
Individuals carrying ε4 allele, developed AD 6.5 times more than non-carriers (OR = 6.52, 95%CI = 2.63-16.17).
There was no significant association between ABCA1 polymorphism and AD.
Conclusion : unlike other studies, R219K polymorphism was not dependent on gender and APOE-ε4 allele and there was no association between APOE and ABCA1 in AD patients compared to controls.
American Psychological Association (APA)
Khorshid, H. R. Khorram& Gozalpour, E.& Kamali, K.& Ohadi, M.& Karimlu, M.& Shahhusayni, M. H.. 2011. The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population. Iranian Red Crescent Medical Journal،Vol. 13, no. 4, pp.256-262.
https://search.emarefa.net/detail/BIM-268285
Modern Language Association (MLA)
Khorshid, H. R. Khorram…[et al.]. The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population. Iranian Red Crescent Medical Journal Vol. 13, no. 4 (Apr. 2011), pp.256-262.
https://search.emarefa.net/detail/BIM-268285
American Medical Association (AMA)
Khorshid, H. R. Khorram& Gozalpour, E.& Kamali, K.& Ohadi, M.& Karimlu, M.& Shahhusayni, M. H.. The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 4, pp.256-262.
https://search.emarefa.net/detail/BIM-268285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 261-262
Record ID
BIM-268285