دراسة تأثير تراكيز متباينة من المستخلص المائي للنعناع mentha spicata في التراكيب النسجية لرئات الفئران البيض

Abstract EN

The aim of this work was to study the effect of different concentrations of Mentha spicata extract on pulmonary tissues in albino mice.

Twenty four male mice3 months age were included in this study Experimental animals were divided randomly into 4 groups, each group consists of 6 mice.

One milliliter of the extract was given orally to the mice of first ,second and third group daily for consecutive seven days with concentrations 3%,5% and 10% respectively .The mice of the fourth group(control group) were given one milliliter of distilled water by the same way of dosage.

The animals were killed in the eighth day then dissected, the lungs were eradicated then fixed in 10% formalin.

, for histological sectioning.

The histological findings of the experimental animals lungs showed the concentration of 10% had sever adverse effects on pulmonary tissue more than the concentrations of3% and 5% .

The results showed an increase in the size of the alveoli and degeneration of their walls, with congestion of alveolar capillaries and infiltration of the alveoli and alveolar walls by inflammatory cell in addition to infiltration of the terminal bronchioles by such inflammatory cells, and degeneration of the epithelial tissue lining such bronchioles.