Preparation of a new dosage form of metoclopramide hydrochloride as orodispersible tablet

Abstract EN

Metoclopramide HCl (MTB) is a potent antiemetic drug used for the treatment of nausea and vomiting.

Many trials were made to prepare a satisfactory MTB or dispersible tablet using direct compression method.

Various super disintegrates were used in this study which are croscarmellose sodium (CCS), sodium starch glycol ate (SSG) and crospovidone (CP).

The latter was the best in terms of showing the fastest disintegration time in the mouth.Among the different diluents utilized, it was found that a combination of microcrystalline cellulose PH101 (MCC 101), mannitol, dicalcium phosphate dihydrate (DPD) and Glycine was the best in preparing MTB or dispersible tablet with fastest disintegration time in the mouth.

The physical parameters of the prepared MTB or dispersible tablet were satisfactory as hardness (4 Kg), friability (0.5 %) and mouth disintegration (23 sec).

The overall results suggest that the prepared formula of MTB as or dispersible tablet could be utilized as a new dosage form for the oral administration.