Synthesis of 3’ - 3’ - gem – di – C –nitromethyl nucleoside analogues of possible biological activity

Abstract EN

Synthesis of new nucleoside analogues of the type : 3 ̀, 3 ̀- gem–di–C–nitromethly, expected to have useful application in the chemotherapeutic treatment of AIDS, cancer and microbial infections.

The synthesis involved the condensation of the appropriate sugar derivative ( i.e .

3 ̀, 3 ̀–gem–di–Cnitromethly–1– ribofuranose ) with nitrogen bases , such as, uracil and theophllin following a multi-step scheme starting from diacetone golucose (1) (scheme 1) .The prepared compound were identified by spectroscopic methods ; ir, mass, 1H and 13C nmr.