Kaposi’s sarcoma following immunosuppressive therapy for vasculitis

Abstract EN

Kaposi’s sarcoma (KS) is widely reported to develop after renal transplantation and is induced by activation of a latent human herpes virus 8.

We report the clinical features and outcome of a 50-year-old woman who presented with KS 18 weeks after starting immunosuppressive therapy for vacuities.

She had positive-titer IgG antibody to human herpes virus 8.

Cyclophosphamide pulses were interrupted, and prednisone was decreased gradually to 10 mg / day.

Skin lesions showed important regression with stabilization of the general state and renal function.

Eight months later, the patient presented with a diffuse cutaneous KS that required the discontinuation of steroids.

Within 1 month, her general status and renal function deteriorated, and she died with a disseminated intravascular coagulation syndrome.