Gastrointestinal stromal tumor (gist)’s surgical treatment, nci experience
Joint Authors
Khalil, al-Sayyid Ashraf
Fakhr, Ibrahim
al-Zohairy, Muhammad
al-Shahway, Majdi
Jawdah, Iman A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 17, Issue 2 (30 Jun. 2005), pp.56-66, 11 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2005-06-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Purpose : To review the clinical presentation, surgical management, and prognostic factors for gastrointestinal stromal tumors.
Patients and Methods : A prospective study which was carried out between January 2002 and March 2004 on thirty-three patients with gastrointestinal stromal tumor (GIST) at the National Cancer Institute, Cairo University.
All patients were evaluated preoperatively and underwent exploratory laparotomy with a curative intent, they were followed up for period ranging between 14-35 months.
Results : Among the 33 patients there were 17 males and 16 females.
The mean age of patients was 52.8 years.
Clinical findings included gastrointestinal bleeding (42.4 %), palpable mass (33.3 %) and abdominal pain (24.3 %).
The stomach was the most common site of origin of the disease (39.4 %), followed by the colorectal region (24.2 %).
Tumors were high grade in 63.6 % of patients and low-grade in 36.4 % of patients.
Complete resection of all gross disease was accomplished in 26 patients (78.7 %), among whom, multiple adjacent organ resection was required in 6 patients (22.2 %) and metastatic disease was identified in the liver in 3 patients at the time of exploratory surgery of these one could be resected.
Immunohistochemical staining for CD117 was positive in 88.9 % of patients.
The median follow-up period was 20 months (range, 14-35 months).
The overall median survival in this study was 25 months, and the cumulative survival at 30 months was 46.9 %.
Unfavorable prognostic factors were incomplete resection and, high-grade histological features (p < 0.05).
None of the patients received adjuvant or palliative chemotherapy.
Twenty six patients (78.8 %) are alive free of disease.
Of the 7 patients with incomplete resections or biopsy only ; 4 patients (12.1 %) are alive with disease and 3 patients died.
Conclusion : Surgical resection, including en bloc resection of locally advanced tumors, remains the only curative treatment.
Overall survival is significantly affected by high-grade tumors and positive resection margin.
American Psychological Association (APA)
al-Zohairy, Muhammad& Khalil, al-Sayyid Ashraf& Fakhr, Ibrahim& al-Shahway, Majdi& Jawdah, Iman A.. 2005. Gastrointestinal stromal tumor (gist)’s surgical treatment, nci experience. Journal of the Egyptian National Cancer Institute،Vol. 17, no. 2, pp.56-66.
https://search.emarefa.net/detail/BIM-29686
Modern Language Association (MLA)
Jawdah, Iman A.…[et al.]. Gastrointestinal stromal tumor (gist)’s surgical treatment, nci experience. Journal of the Egyptian National Cancer Institute Vol. 17, no. 2 (Jun. 2005), pp.56-66.
https://search.emarefa.net/detail/BIM-29686
American Medical Association (AMA)
al-Zohairy, Muhammad& Khalil, al-Sayyid Ashraf& Fakhr, Ibrahim& al-Shahway, Majdi& Jawdah, Iman A.. Gastrointestinal stromal tumor (gist)’s surgical treatment, nci experience. Journal of the Egyptian National Cancer Institute. 2005. Vol. 17, no. 2, pp.56-66.
https://search.emarefa.net/detail/BIM-29686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65-66
Record ID
BIM-29686