Serum level of P٥٣ antibody and tissue expression of P٥٣ in breast cancer

Abstract EN

Mutation of the p 53 tumor suppressor gene is common event in breast cancer.

This alteration can result in cellular accumulation of p 53 and may also found in serum p 53 -antibodies.

The current study was established to investigate the correlation between the appearance of the serum p 53 -antibodies and tissue expression of p 53 -antibodies and clinic pathological features in patients.

Serum p 53 antibodies levels were investigated in 40 breast cancer patients, 20 adenofibrosis patients control and in 20 healthy controls by ELISA.

Immunohistochemical assay for tissue expression of the p 53 mutant protein was also undertaken in the same patients with breast cancer.

The median serum levels of p 53-antibodies in breast cancer patients were significantly higher than those in patients control and healthy individuals (p < 0.

05).

Antibody against p 53 was detected in the sera of 8 patients (20 %) whereas the mutant p 53 protein was delected in 16 (40 %) the breast cancer tissue.

Moreover significant correlation was found between serum p 53 protein (p < 0.

05).

Interestingly, the positive rate of p 53-antibodes in breast cancer were related to the absence of steroid hormone receptors (p <0.

05).

These results indicated that the presence of p 53-the size of tumor (p > 0.

05).

These results indicated that the presence of p 53-antibodies is probably triggered by the accumulation of tumor p 53 proteins, and it could be a useful marker to complement routine prognostic factors in breast cancer patients.