Cefotaxime–heparin lock prophylaxis against hemodialysis catheter- related sepsis among staphylococcus aureus nasal carriers
Joint Authors
al-Hafiz, Abd al-Aziz
Abu Oyun, Bassam
al-Milhim, Khalifah
Panhotra, Bodh R.
Saxena, Anil K.
Sundaram, Dasappan S.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 4 (31 Aug. 2012), pp.743-754, 12 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-08-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Topics
Abstract EN
Staphylococcus aureus nasal carriers undergoing hemodialysis (HD) through tunneled cuffed catheters (TCCs) form a high-risk group for the development of catheter-related bloodstream infections (CRBSI) and ensuing morbidity.
The efficacy of antibiotic-locks on the outcomes of TCCs among S.
aureus nasal carriers has not been studied earlier.
Persistent nasal carriage was defined by two or more positive cultures for methicillin-susceptible (MSSA) or methicillin-resistant (MRSA) S.
aureus of five standardized nasal swabs taken from all the participants dialyzed at a large out-patient HD center affiliated to a tertiary care hospital.
Of 218 participants, 82 S.
aureus nasal carriers dialyzed through TCCs (n = 88) were identified through April 2005 to March 2006 and randomized to two groups.
Group I comprised of 39 nasal carriers who had TCCs (n = 41) “locked” with cefotaxime / heparin while group II included 43 patients with TCCs (n = 47) filled with standard heparin.
The CRBSI incidence and TCC survival at 365 days were statistically compared between the two groups.
A significantly lower CRBSI incidence (1.47 vs.
3.44 / 1000 catheter-days, P < 0.001) and higher infection-free TCC survival rates at 365 days (80.5 vs.
40.4 %, P < 0.0001) were observed in the cefotaxime group compared with the standard heparin group.
However, no significant difference in MRSA-associated CRBSI incidence was observed between the two groups.
Cefotaxime-heparin “locks” effectively reduced CRBS Incidence associated with gram-positive cocci, including MSSA, among S.
aureus nasal carriers.
There remains a compelling requirement for antibiotic-locks effective against MRSA.
American Psychological Association (APA)
Saxena, Anil K.& Panhotra, Bodh R.& al-Hafiz, Abd al-Aziz& Sundaram, Dasappan S.& Abu Oyun, Bassam& al-Milhim, Khalifah. 2012. Cefotaxime–heparin lock prophylaxis against hemodialysis catheter- related sepsis among staphylococcus aureus nasal carriers. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 4, pp.743-754.
https://search.emarefa.net/detail/BIM-312209
Modern Language Association (MLA)
Saxena, Anil K.…[et al.]. Cefotaxime–heparin lock prophylaxis against hemodialysis catheter- related sepsis among staphylococcus aureus nasal carriers. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 4 (Aug. 2012), pp.743-754.
https://search.emarefa.net/detail/BIM-312209
American Medical Association (AMA)
Saxena, Anil K.& Panhotra, Bodh R.& al-Hafiz, Abd al-Aziz& Sundaram, Dasappan S.& Abu Oyun, Bassam& al-Milhim, Khalifah. Cefotaxime–heparin lock prophylaxis against hemodialysis catheter- related sepsis among staphylococcus aureus nasal carriers. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 4, pp.743-754.
https://search.emarefa.net/detail/BIM-312209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 752-754
Record ID
BIM-312209