Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children
Joint Authors
Nur al-Din, Usamah
Abd al-Dayim, Suha M.
Shatla, Raniayh Hamid
Imarah, Nahed A.
al-Jammal, Sarah S.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 3 (31 Dec. 2012), pp.275-280, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
The relationship between increased homocysteine (Hcy) level and epileptic seizure remains controversial in human, despite a growing evidence of the pro-convulsive effect of the hyperhomocysteinemia (HHcy) observed in the animal studies.
The mechanism of this association with epileptogenesis has not been clearly understood, although there is emerging evidence to support the unfavorable effects of some anti-epileptic drugs (AEDs) on the plasma homocysteine (Hcy) concentrations.
The aim of this study was to uncover the relationship between the levels of homocysteine (Hcy), the cofactors involved in its metabolism as folic acid and vitamin B12 and anti-epileptic drugs (AEDs) in epileptic patients.
Serum level of homocysteine (Hcy), folic acid and vitamin B12 was measured in 60 patients with idiopathic epilepsy; and its level was compared to 30 healthy children serving as control group.
No significant difference was found regarding the plasma homocysteine (Hcy) levels between patients (both receiving anti-epileptics and non-anti-epileptic drug users) and controls.
Epileptic patients on polytherapy showed higher mean serum levels of homocysteine (Hcy) and lower mean serum levels of folic acid compared to those on immunotherapy.
However, the mean serum levels of homocysteine (Hcy), vitamin B12 and folic acid showed non-significant differences between patients using valproic acid (VPA) or carbamazepine (CBZ).
Duration of AED therapy showed a significant positive correlation with mean serum levels of homocysteine (Hcy) and a significant negative correlation with mean serum levels of folic acid.
To conclude ; AEDs upset the homeostatic balance of homocysteine (Hcy) and its cofactors and cause abnormalities in their serum levels.
American Psychological Association (APA)
Nur al-Din, Usamah& Abd al-Dayim, Suha M.& Shatla, Raniayh Hamid& Imarah, Nahed A.& al-Jammal, Sarah S.. 2012. Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 3, pp.275-280.
https://search.emarefa.net/detail/BIM-313013
Modern Language Association (MLA)
Nur al-Din, Usamah…[et al.]. Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 3 (2012), pp.275-280.
https://search.emarefa.net/detail/BIM-313013
American Medical Association (AMA)
Nur al-Din, Usamah& Abd al-Dayim, Suha M.& Shatla, Raniayh Hamid& Imarah, Nahed A.& al-Jammal, Sarah S.. Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 3, pp.275-280.
https://search.emarefa.net/detail/BIM-313013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 279-280
Record ID
BIM-313013