تأثير المستخلص التربيني لبذور نبات الخروع Ricinus communis seed في بعض جوانب معايير الخصوبة لدى ذكور الجرذان البيض

Abstract EN

45 albino rats males and 30 females were used in this study , The males were divided in three groups as 15 rat in each group , The first group ( the control group ) administration with with the physiological solution for 50 days , the second and third groups administrated with 20 and 40 mg/ kg of terpinoid extract of Ricinus communis seed respectively for 50 days .

after 24 hr.

after last administration , 10 animals of each groups were be sacrificed , while the rats 5 animals were put with normal females for fertility test .

the results showed a significant decrease of the body weight rats and the weight of testes , epididymis , semin vesicles , prostate and pre putial gland of the animals treated with 20 and 40 mg / kg with extracts in comparison with the control group .

also the rats showed that both concentration ( 20 and 40 mg / kg ) caused a decrease in the sperm activity and the percentage of sperm motility and sperm viability and an increase in the percentage of dead sperm and abnormal sperm in the tail of the epididymis .

The results showed significant decrease in the absolute weight of sertoli cells and the basement membrane , and the rat epididymal diameter and the diameter seminiferous tubules .

also the results showed a significant decrease in the testosterone level and a significant increase in the rat concentration and the follicles stimulating hormone FSH , and a significant decrease in the concentration of the leutinizig hormone and a decrease in the absolute weight of the composition of spermatogenetsis in the siminiferous tubules when these results compared with the control group .

also the results showed a significant decrease in the number leydig cells and sertoli cells .

The fertility test showed that the fertilization did not occur in the females which were put with treated animals .

The conclusions of this study that there is a negative effects of the terpinoid extracts of Ricinus communis seed in the parameters studied in this search .

The search aimed to determined the side effect of the Ricinus communis seed in the reproductive male parameters