Serum uric acid as a predictor of short-term mortality and heart failure in acute myocardial infarction

Abstract EN

This study aimed to determine the association of SUA levels with short term ( in hospital) outcome following acute myocardial infarction. The study included 100 patients presented with acute ST-elevation myocardial infarction (STEMI), serum uric acid (SUA) levels were measured within the 1st 12 hour of admission to coronary care unit. 13 patients had high serum uric acid(E450 μmol / L) and 87 patients had normal SUA. serum uric acid died.

23 % of patients with high serum uric acid developed heart failure (HF), while 6.8 % of patients with normal serum uric acid developed heart failure.

40 % of male patients with high SUA developed cardiac complications (HF and cardiac death)while 8.3 % of male patients with normal SUA developed cardiac complications, 66.6 % of female patients with high SUA developed cardiac complications, while 11.1 % of female patients with normal SUA developed cardiac complications.

The differences were significant(P value < 0.05) The predictive value of SUA was significant in patients aged E 60 years and in those aged < 60 years, as well as in smokers and non smokers, and in those with high BMI, and in patients with increased serum lipids and those with normal lipid profile . The predictive value of SUA was not significant in hypertensive patients, while it was significant in normotensive patients.

15.6 % of patients not received thrombolytic therapy developed elevation of SUA, while non (0 % ) of patients received thrombolytic therapy developed elevation of SUA.

18.5 % of patients with multiple regions MI (by ECG localization) developed elevation of SUA, while 8.3% of patients with inferior MI developed elevation of SUA, while non (0 % ) of patients with lateral MI developed elevation of SUA.

By this study it appeared that high SUA levels was associated with higher risk of death and development of heart failure during the hospitalization period, and it may be considered as a prognostic marker for MI complications.