Effect of the combination of ethinyl oestradiol and cyproterone acetate on menstrual regulation, endocrine and utrasonographic profile in single women with polycystic ovary syndrome

Abstract EN

The aim of the study was to investigate the effect of administration of cyproterone acetate / ethinyl oestradiol (CPA / EE) combination (Diane 35) on the menstrual regulation, endocrine and ultrasonographic profile in women with polycystic ovary syndrome(PCOS).

17 single PCOS patients were treated with 2 mg cyproterone acetate and 35μg ethinyl oestradiol for 12 cycles.

Assessment of menstrual cycle pattern, ultrasonographic pelvic examination and evaluation of the hormonal profile were performed at base line and after three, six and 12 months of treatment.

All women attained satisfactory cycle control.

Plasma level of luteinizing hormone (LH), testosterone significantly fell from the third cycle on with a significant decrease in ovarian size and volume and a reduction in microcysts number and size.

The CPA / EE combination seems to be ef.