تأثير عصير جذور الجزر (Daucus carota)‎ و عقار السايكلوفوسفومايد في حث تشوهات النطف في الفئران البيض Mus musculus

Abstract EN

The effect of carrot juice on sperm-head abnormalities was studied in white mice after oral administration , in addition to the effect of cyclophosphamide (Cp) and their interactions in different combinations .

Results indicated that carrot juice (0.1 , 0.25 , 0.5 ) ml administrated orally had no effect compared to the background baseline abnormalities .

Cp (50mg / Kg of body weight) elevated the abnormalities to 9 – 15 times the background level (Negative control) .

These abnormalities were lowered due to the natural repair processes to 5 times on time spans 6 days .

Treatment of animals with carrot juice before mutagen (Ca/Cp) had great effect to reduce the abnormalities , followed by using the juice with mutagen (Ca+Cp) treatment , while using the juice after administration of Cp had slight effect to lower the abnormalities .Types of abnormalities were studied ; the sperms lost the hook was induced greatly by Cp and by treatment (Ca+Cp) .

However , most types of abnormalities such as sperm with atrophic head or with spherical heads , sperm with hammer shaped heads and sperm with rod shaped heads were lowered in general at significant levels (P<0.01) compared to positive control and some abnormal sperms were disappeared such as rod shaped sperms .

Using the juice after mutagen treatment (Cp/Ca) was effective in lowering the abnormalities to a significant levels (P<0.01) , but after 6 days and in time depending manner .