A new keynote of β–thalassemia major patients as oxidative stress accompanying

Abstract EN

This study evaluated the total thiols group (-SH), total serum protein, albumin concentration and vitamin E, as well as peroxynitrite in serum as a parameter of peroxidative stress for patients with β–thalassemia major, transfusion dependent, compared with healthy controls.

We found that the levels of total thiols and total protein are significant decreased, while the albumin concentration slightly decreased in patients compared with controls where as the depletion of the vitamin E concentration in serum of patients is accompanying the increasing of peroxynitrite levels.

The results suggest that the measurement of peroxidative product matched with evaluation of antioxidants, may be a simple measure of iron toxicity in thalassemia.