تأثير الموثين F2∝ في التركيب المستدق و الفعالية الخلوية للبنكرياس في ذكور الفئران البيض

Abstract EN

This study includes the injection of male albino mice with six doses of (5 μg / kg body weight) of prostaglandin F2∝ inorder to findout the side effects of prostaglandin F2∝ on ultrastructure and cellular activity of pancreas and to know the possibility of cellular repair process .

This experiment includes two groups injected with prostaglandin F2∝ first killed in 7th day & the second killed in 13th day in addition of control group.

The results was as follows :- 1-A significant decrease (P < 0.01) in animals weight treated with prostaglandin F2∝ which killed in 7th day while no significant differences in the body weight in animals treated with prostaglandin F2∝ & killed in 13th day.

2-A significant decrease in the pancreas / body weight ratio was observed in prostaglandin F2∝ treated group which killed in 7th day while a significant increase (P > 0.05) in prostaglandin F2∝ treated group which killed in 13th day.

3-The Transmission Electron Microscopical study results revealed that the prostaglandin F2∝ has a negative effect on pancreatic cells represented by degenerative changes such as apoptosis in most acini & beta cells which reflect a decrease in the pancreas / body weight ratio, while no changes were seen in the secretory activity of alpha cells.

After six days from prostaglandin F2∝ injection a slight repair process in the cellular appearance was observed.