تأثير المستخلص المائي البارد و المركب البروتيني المعزول من لحاء الدارسين (Cinnamomum cassia)‎ في مستويات الكلوكوز و الدهون البروتينية في مصل دم الفئران

Abstract EN

One proteinous component had been isolated from gel filtration chromatography of the full saturated precipitate produced by ammonium sulphate of the aqueous extract of the Cinnamomum cassia bark.

The apparent molecular weight of the isolated component was found to be (6558) dalton using gel filtration chromatography and (6732) dalton using sodium dodecyl sulphate poly aery I amide gel electrophoresis.

The results showed that the cold crude aqueous extract non-proteineous extract and proteinous component isolated from aqueous extract were lowered glucose level using a dose of 100 mg / kg weight.

The percent decrease were (38 %, 21 % and 25 %) respectively in normal micc.

where as in diabetic mice, the proteinous component isolated from aqueous extract was the most effective in lowering glucose level using a dose of 100 mg / kg body weight where the percent decrease was 85 %.

Finally, the crude aqueous extract and proteinous component isolated from the cold aqueous extract showed a significant decrease in the level of total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL-C) and low density lipoprotein (LDL-C) in normal mice.

However, in diabetic mice, the cold non-proteinous extract was the most effective in lowering TC, TG, VLDL-C, LDL-C and HDL-C levels.