Evaluation the antioxidant effect of α-L- Fucose injection into rabbit periodontium

Abstract EN

Background: α-L-Fucose is a methyl pentose sugar similar to L-galactose except for the loss of alcohol group on carbon number 6.

The objective of this study is to evaluate the biochemical and antioxidant effect of intracrevicular injection of fucose into rabbits periodontium, throughout measuring the levels of total protein (TP), total fucose (TF), protein bound fucose PBF) , Malondialdehyde (MDA) , and vitamin C in sera of fucose injected rabbit groups.( Materials and Methods: The existing study was carried out on 55 male rabbits and were divided randomly into three groups ; first group was injected with 50μl of 150mM fucose solution into gingival sulcus ; second group was injected with 50 μl of normal saline ; while the third group was not received any injection ( normal group) .Blood samples were collected from injected groups at time intervals of 1, 3 ,24 ,72, and 168 hours after injection, for measuring of serum TP, TF, , PBF , MDA, and vitamin C and compared with normal group.

Results: The results showed a significant increase in the mean concentration of TF and PBF reaching its maximum value 3hrs after injection, then it decline until reached its normal value 168 hours after injection, whereas serum total protein increased significantly only 3 hours after injection.

Also serum MDA level did not change after injection, while serum vitamin C increased immediately after fucose injection, even 72 hours after injection.

Conclusion: Intracrevicular injection of α-L- Fucose has an observable effect on TF and PBF this may give an indication about its effect on periodontal tissue and has a role in the body defence against oxidative stress, throughout increasing the production of vitamin C.