Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts
Joint Authors
Ramadan, A.
Sulayman, G.
Mahmud, Sawsan S.
Nawfal, Salwa M.
Abd al-Rahman, Rihab F.
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 1 (31 Jan. 2012), pp.13-21, 9 p.
Publisher
Publication Date
2012-01-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
The possible toxicological effects and in vitro antioxidant activity of the ethanolic extracts of Crocus sativus and Propolis were investigated.
Both extracts did not cause any mortalities or signs of toxicity in mice when administered orally at doses up to 5 g/kg b.wt.
In the sub-chronic study; the tested extracts did not produce any significant change in liver and kidney functions of rats, following oral administration for 8 successive weeks at doses of 500 mg / kg b.wt.
of each.
Propolis showed remarkable in vitro antioxidant activity at concentrations of (40-100 mg / ml).
In contrast, the ethanolic extract of C.
sativus ethanolic extract showed weak antioxidant activity in concentrations of (1–10 mg / ml) while at concentrations of (20-100 mg / ml) failed to exhibit any antioxidant activity.
It was concluded that: both extracts were non-toxic, as they did not cause any mortalities or signs of toxicity in mice when administered orally at doses up to 5 g / kg b.wt.
Daily oral administration of C.
sativus, Propolis ethanolic extracts alone or in combination for 8 successive weeks to rats was quiet safe and didn’t cause any toxic changes in liver and kidney.
Antioxidant study showed that Propolis ethanolic extract was a more potent antioxidant than C.
sativus extract.
American Psychological Association (APA)
Ramadan, A.& Sulayman, G.& Mahmud, Sawsan S.& Nawfal, Salwa M.& Abd al-Rahman, Rihab F.. 2012. Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts. Journal of Saudi Chemical Society،Vol. 16, no. 1, pp.13-21.
https://search.emarefa.net/detail/BIM-351965
Modern Language Association (MLA)
Ramadan, A.…[et al.]. Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts. Journal of Saudi Chemical Society Vol. 16, no. 1 (Jan. 2012), pp.13-21.
https://search.emarefa.net/detail/BIM-351965
American Medical Association (AMA)
Ramadan, A.& Sulayman, G.& Mahmud, Sawsan S.& Nawfal, Salwa M.& Abd al-Rahman, Rihab F.. Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 1, pp.13-21.
https://search.emarefa.net/detail/BIM-351965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 20-21
Record ID
BIM-351965