Evaluation the levels of plasma interleukins (IL-8, IFN-γ, IL-10)‎ in preeclamptic pregnancies

Abstract EN

This study is to evaluate plasma levels of several cytokines in preeclamptic pregnancies compared to those of healthy pregnancies.

Ninety pregnant women with preeclampsia (37 mild & 53 severe) and thirty healthy pregnant women were enrolled in the study.

Blood samples were taken and plasma levels of IL-8, IL-10, and IFN-γ were measured by enzyme-linked immunosorbent assay (ELISA).

Preeclamptic women and their severe cases but not mild cases had significantly (P < 0.05) increased levels of plasma IL-8, and IFN-γ as compared with healthy pregnancies.

By contrast, plasma levels of IL-10 was significantly (P < 0.05) increased in healthy pregnant women as compared to all groups of preeclampsia.

Preeclampsia is associated with an imbalance between pro-inflammatory cytokines (IL-8, IFN-γ) and anti-inflammatory cytokines (IL-10), and these support our suggestion of altered immune response in preeclampsia.