تأثير خميرة Candida albicans في بعض المعايير الدموية و الكيموحيوية في الفئران المختبرية

Abstract EN

In the present study, 32 white mice Balb / C (two months age) were used, there were divided into four equal groups.

Three groups were injected with fungal suspention of candida albicans in doses of 1 x 106, 1 x 108 and 3 x 108 cell / ml, whereas the fourth group was regarded as control and injected with 0.5 ml normal saline solution.

All were dissected after 6 days of injection to study the physiological effect of the yeast on blood, which include RBCand WBC count, Hb concentration and PCV ratio.

And on biochemical content which include the determination of protein, glycogen and cholestrol in liver, kidney and muscles.

The results showed that the number of RBC were decreased, while WBC were increased in the injected mice, but there were no signifficant effect on PCV and Hb.

On the other hand,cholestrol values were decreased significantly in the injected mice in comparison with control, but this decrease was varied in different tissues (P > 0.01).

The value was lower in liver, whereas no signifficant difference was found between Kidney and muscles.

Protein values were not signifficantly different in comparison with control, but it was different among tissue studied.

Muscles was the highest value and the liver was lowest.

Glycogen decreased signifficantly in comparison with control, but not among tissues.