بعض الجوانب المرضية لجرثومة Campylobacter jejuni المعزولة من حالات الإسهال في الأطفال

Abstract EN

The study aimed to elucidating some pathogenecity factors of Campylobacter jejuni isolated from sever diarrhoeal cases from children at age of less than two years old, due to the association between this bacterium and these cases.

The factors studied included such its adherence to eucaryotic cells by using oral epithelial cells isolated from human.

The bacterium showed ability of adherence on these cells.

The ability to produce enterotoxin and its effect through injection intraperitoneally in the mice was also investigated.

After three days the mice were killed and histological sections were prepared from small intestine, large intestine and liver.

The microscopical results for these sections showed vascular degeneration in the cytoplasm of hepatocytes and lymphocytic perivascular cuffing surrounded the centeral vein, as well as dilatation of the lumen, In small intestine there is atrophy of villi, severe coagulative necrosis in epithelial lining of the mucosal layer and infiltration of inflamentary cells while in large intestine there was elongation of some villi and atrophy in others.

Infiltration of inflamentary cells was also noticed.