Measurement serum levels of IFNγ, IL-17 and IL-4 of psoriasis patients in al-Najaf City

Abstract EN

Background : Psoriasis is an inflammatory skin disorder characterized by activation of lymphocytes, systemic and local over expression of pro-inflammatory cytokines.

Objectives :- The study was designed to investigate the level of cytokines in patients with psoriasis and study the correlation of the cytokines with disease severity.

Patients and Methods : Blood samples were collected from seventy patients with psoriasis for measurement of (IFNγ, IL-17 and IL-4) by ELISA technique.

Results : High levels of IFNγ and IL-17 were observed in patients with psoriasis.

It was found that the mean levels of IFNγ and IL-17 were significantly correlated to disease severity.

Moreover, the mean level of IL-4 in psoriatic patient was found to decrease significantly according to graded severity of the disease.

Statistical analysis was done by using SPSS (statistical package for social sciences) in which T-test and ANOVA test were used and chi- square (X2) test for categorical data.

Conclusion : The study concluded that the level of IFNγ and IL-17 may play a key role as an indicator in the immunopathogenesis of psoriasis and markers of disease activity.

Recommendation : Using another cytokines and study effect of these cytokines with disease severity.