Synthesis and charactrazation of some γ-lactams compounds by using [2+3] cycloaddition reaction

Abstract EN

-This study is concerned with the synthesis and characterization of the γ-lactams 3(af), These compounds were prepared by reacting 2-bromobenzoyl chlorides with the appropriate imine 2(a-f), in the presence of phenyllithuim in tetrahydrofuran (THF) at 0˚C.

Addition of 2-bromobenzoyl chlorides to imines affords N-acyliminium ions as adducts.

Subsequent reaction of these adducts with phenyllithium at -5˚C to afford γ-lactams (a-f) in moderate yields(55-73%).and confirmed these compounds by spectral data IR,UV,1H-NMR and Mass spectra.