Univariate and multiple linear regression analyses for 23 single nucleotide polymorphisms in 14 genes predisposing to chronic glomerular diseases and IgA nephropathy in Han Chinese
Joint Authors
Sui, Weiguo
Chen, Jiejing
Wang, Hui
Xue, Wen
Wu, Junyong
Dai, Yong
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 5 (31 Oct. 2014), pp.992-997, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-10-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Immunoglobulin A nephropathy (IgAN) is a complex trait regulated by the interaction among multiple physiologic regulatory systems and probably involving numerous genes, which leads to inconsistent findings in genetic studies.
One possibility of failure to replicate some single-locus results is that the underlying genetics of IgAN nephropathy is based on multiple genes with minor effects.
To learn the association between 23 single nucleotide polymorphisms (SNPs) in 14 genes predisposing to chronic glomerular diseases and IgAN in Han males, the 23 SNPs genotypes of 21 Han males were detected and analyzed with a BaiO gene chip, and their associations were analyzed with univariate analysis and multiple linear regression analysis.
Analysis showed that CTLA4rs231726 and CR2rs1048971 revealed a significant association with IgAN.
These findings support the multi-gene nature of the etiology of IgAN and propose a potential gene-gene interactive model for future studies.
American Psychological Association (APA)
Wang, Hui& Sui, Weiguo& Xue, Wen& Wu, Junyong& Chen, Jiejing& Dai, Yong. 2014. Univariate and multiple linear regression analyses for 23 single nucleotide polymorphisms in 14 genes predisposing to chronic glomerular diseases and IgA nephropathy in Han Chinese. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 5, pp.992-997.
https://search.emarefa.net/detail/BIM-400227
Modern Language Association (MLA)
Wang, Hui…[et al.]. Univariate and multiple linear regression analyses for 23 single nucleotide polymorphisms in 14 genes predisposing to chronic glomerular diseases and IgA nephropathy in Han Chinese. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 5 (2014), pp.992-997.
https://search.emarefa.net/detail/BIM-400227
American Medical Association (AMA)
Wang, Hui& Sui, Weiguo& Xue, Wen& Wu, Junyong& Chen, Jiejing& Dai, Yong. Univariate and multiple linear regression analyses for 23 single nucleotide polymorphisms in 14 genes predisposing to chronic glomerular diseases and IgA nephropathy in Han Chinese. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 5, pp.992-997.
https://search.emarefa.net/detail/BIM-400227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 996-997
Record ID
BIM-400227