Subcutis calcinosis caused by injection of calcium-containing heparin in a chronic kidney injury patient
Joint Authors
Bin Maiz, Hedi
Krid, Madihah
al-Ati, Zahrah
Rayyis, Lamya
Biji, Sumayyah
Zouaghi, Karim
Azzuz, Haifa
Zaytunah, Munsif
Bin Fatimah, Layla
Bin Musa, Fatimah
Samawi, Wided
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 5 (31 Oct. 2014), pp.1068-1071, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-10-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Patients
- Kidneys
- Calcium
- Diseases
- Drugs
- Therapeutics
- Congenital malformations
- Complications(Medicine)
- Kidney failure
- Coagulation
- Calcinosis
Abstract EN
Subcutis calcinosis, characterized by abnormal calcium deposits in the skin, is a rare complication of using calcium-containing heparin occurring in patients with advanced renal failure.
We report the case of an 83-year-old female, a known case of chronic kidney disease (CKD) for four years with recent worsening of renal failure requiring hospitalization and hemodialysis.
She developed subcutis calcinosis following injection of calcium-containing heparin.
Biochemical tests showed serum parathormone level at 400 pg / dL, hypercalcemia, elevated calcium-phosphate product and monoclonal gammopathy related to multiple myeloma.
She developed firm subcutaneous nodules in the abdomen and the thighs, the injection sites of Calciparin® (calcium nadroparin) that was given as a preventive measure against deep vein thrombosis.
The diagnosis of subcutis calcinosis was confirmed by the histological examination showing calcium deposit in the dermis and hypodermis.
These lesions completely disappeared after discontinuing calcium nadroparin injections.
Subcutis calcinosis caused by injections of calcium-containing heparin is rare, and, to the best our knowledge, not more than 12 cases have been reported in the literature.
Pathogenesis is not well established but is attributed to the calcium disorders usually seen in advanced renal failure.
Diagnosis is confirmed by histological tests.
Outcome is mostly favorable.
The main differential diagnosis is calciphylaxis, which has a poor prognosis.
Even though rarely reported, we should be aware that CKD patients with elevated calcium-phosphorus product can develop subcutis calcinosis induced by calcium-containing heparin.
When it occurs, fortunately and unlike calciphylaxis, outcome is favorable.
American Psychological Association (APA)
Bin Fatimah, Layla& al-Ati, Zahrah& Azzuz, Haifa& Rayyis, Lamya& Krid, Madihah& Biji, Sumayyah…[et al.]. 2014. Subcutis calcinosis caused by injection of calcium-containing heparin in a chronic kidney injury patient. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 5, pp.1068-1071.
https://search.emarefa.net/detail/BIM-400450
Modern Language Association (MLA)
Bin Fatimah, Layla…[et al.]. Subcutis calcinosis caused by injection of calcium-containing heparin in a chronic kidney injury patient. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 5 (2014), pp.1068-1071.
https://search.emarefa.net/detail/BIM-400450
American Medical Association (AMA)
Bin Fatimah, Layla& al-Ati, Zahrah& Azzuz, Haifa& Rayyis, Lamya& Krid, Madihah& Biji, Sumayyah…[et al.]. Subcutis calcinosis caused by injection of calcium-containing heparin in a chronic kidney injury patient. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 5, pp.1068-1071.
https://search.emarefa.net/detail/BIM-400450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1071
Record ID
BIM-400450