Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation
Joint Authors
Dai, Yong
Huang, Yuanshuai
Lv, Tianyu
Wang, Kang
Li, Deping
Liu, Jianjun
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 6 (31 Dec. 2008), pp.952-959, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
At present, the diagnosis of renal allograft rejection requires a renal biopsy.
Clinical management of renal transplant patients would be improved if rapid, noninvasive and reliable biomarkers of rejection were available.
This study is designed to determine whether such protein biomarkers can be found in renal-graft tissue proteomic approach.
Orthotopic kidney transplantations were performed using Fisher (F344) or Lewis rats as donors and Lewis rats as recipients.
Hence, there were two groups of renal transplant models: one is allograft (from F344 to Lewis rats); another is syngrafts (from Lewis to Lewis rats) serving as control.
Renal tissues were collected 3, 7 and 14 days after transplantation.
As many as 18 samples were analyzed by 2D Electrophoresis and mass spectrometry (MALDI-TOF-TOF-MS).
Eleven differentially expressed proteins were identified between groups.
In conclusion, proteomic technology can detect renal tissue proteins associated with acute renal allograft rejection.
Identification of these proteins as diagnostic markers for rejection in patients' urine or sera may be useful and noninvasive, and these proteins might serve as novel therapeutic targets that also help to improve the understanding of mechanism of renal rejection.
American Psychological Association (APA)
Dai, Yong& Lv, Tianyu& Wang, Kang& Huang, Yuanshuai& Li, Deping& Liu, Jianjun. 2008. Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 6, pp.952-959.
https://search.emarefa.net/detail/BIM-40183
Modern Language Association (MLA)
Dai, Yong…[et al.]. Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 6 (Dec. 2008), pp.952-959.
https://search.emarefa.net/detail/BIM-40183
American Medical Association (AMA)
Dai, Yong& Lv, Tianyu& Wang, Kang& Huang, Yuanshuai& Li, Deping& Liu, Jianjun. Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 6, pp.952-959.
https://search.emarefa.net/detail/BIM-40183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 958-959
Record ID
BIM-40183