Gabapentin : a promising drug for the treatment of uremic pruritus
Joint Authors
Harandi, Ali Amini
Naini, Afsoon Imami
Khanbabapour, Saeid
Shahidi, Shahrzad
Mohseni, Masud
Seirafian, Shiva
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 18, Issue 3 (31 Dec. 2007), pp.378-381, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2007-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Patients
- Sensory systems
- Antiepileptic drugs
- Therapeutics
- Hemodialysis
- Complications(Medicine)
- Uremic pruritus
Abstract EN
Despite advances made in treatment, uremic pruritus remains a common and distressing symptom in patients on hemodialysis (HD).
Gabapentin is an effective drug in the management of neuropathic pain.
Considering that neuropathic pain and pruritus share similar pathogenic mechanisms, we conducted this study to evaluate the efficacy of gabapentin in controlling uremic itch.
In a double blind, placebo-controlled trial, 34 adult patients on maintenance HD were enrolled.
The patients were assigned to receive four weeks of treatment with either gabapentin (400 mg) or placebo administered twice weekly after HD sessions.
Pruritus scores were measured using a visual analogue scale and compared between the two groups.
After four weeks of treatment, the mean decrease in pruritus score in gabapentin and placebo groups was 6.7 ± 2.6 and 1.5 ± 1.8, respectively (p < 0.001).
None of the patients was forced to drop out of the study due to side effects of the treatment.
Our study suggests that gabapentin is a safe and effective treatment for uremic itch.
American Psychological Association (APA)
Naini, Afsoon Imami& Harandi, Ali Amini& Khanbabapour, Saeid& Shahidi, Shahrzad& Seirafian, Shiva& Mohseni, Masud. 2007. Gabapentin : a promising drug for the treatment of uremic pruritus. Saudi Journal of Kidney Diseases and Transplantation،Vol. 18, no. 3, pp.378-381.
https://search.emarefa.net/detail/BIM-40843
Modern Language Association (MLA)
Naini, Afsoon Imami…[et al.]. Gabapentin : a promising drug for the treatment of uremic pruritus. Saudi Journal of Kidney Diseases and Transplantation Vol. 18, no. 3 (Dec. 2007), pp.378-381.
https://search.emarefa.net/detail/BIM-40843
American Medical Association (AMA)
Naini, Afsoon Imami& Harandi, Ali Amini& Khanbabapour, Saeid& Shahidi, Shahrzad& Seirafian, Shiva& Mohseni, Masud. Gabapentin : a promising drug for the treatment of uremic pruritus. Saudi Journal of Kidney Diseases and Transplantation. 2007. Vol. 18, no. 3, pp.378-381.
https://search.emarefa.net/detail/BIM-40843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 380-381
Record ID
BIM-40843