Synthesis and pharmacological evaluation of 5-[2’-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4, 5, 6, 7-tetrahydro-thieno [3, 2-c] pyridine derivatives as platelet aggregation inhibitors
Joint Authors
Challa, Nageswar Rao
Mamidisetty, Balaji
Ghanta, Mahesh Reddy
Padi, Pratap Reddy
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 5 (31 Dec. 2014), pp.513-519, 7 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
One pot synthesis and characterization of new 5-[20-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4, 5, 6, 7-tetrahydro-thieno [3, 2-c] pyridines (3a-k) using amides (2a-k) were reported.
The prepared 5-[20-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5,6,7-tetrahydro-thieno [3,2-c] pyridine (3a) is a bioisostere of 40-(6,7-dihydro-4H-thieno [3,2-c]pyridin-5-ylmethyl)-biphenyl-2-carboxylic acid (1), having good in vivo antithrombotic activity compared with Clopidogrel.
The new tetrazole derivatives (3a-k) were screened for their in vitro activity as platelet aggregation inhibitors.
American Psychological Association (APA)
Challa, Nageswar Rao& Mamidisetty, Balaji& Ghanta, Mahesh Reddy& Padi, Pratap Reddy. 2014. Synthesis and pharmacological evaluation of 5-[2’-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4, 5, 6, 7-tetrahydro-thieno [3, 2-c] pyridine derivatives as platelet aggregation inhibitors. Journal of Saudi Chemical Society،Vol. 18, no. 5, pp.513-519.
https://search.emarefa.net/detail/BIM-412839
Modern Language Association (MLA)
Challa, Nageswar Rao…[et al.]. Synthesis and pharmacological evaluation of 5-[2’-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4, 5, 6, 7-tetrahydro-thieno [3, 2-c] pyridine derivatives as platelet aggregation inhibitors. Journal of Saudi Chemical Society Vol. 18, no. 5 (2014), pp.513-519.
https://search.emarefa.net/detail/BIM-412839
American Medical Association (AMA)
Challa, Nageswar Rao& Mamidisetty, Balaji& Ghanta, Mahesh Reddy& Padi, Pratap Reddy. Synthesis and pharmacological evaluation of 5-[2’-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4, 5, 6, 7-tetrahydro-thieno [3, 2-c] pyridine derivatives as platelet aggregation inhibitors. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 5, pp.513-519.
https://search.emarefa.net/detail/BIM-412839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 519
Record ID
BIM-412839