دور الترانس غلوتاميناز في تشخيص الداء الزلاقي عند الأطفال

Abstract EN

Objective: To study the trans glutaminase textile (t.TG) IgA in celiac disease, and whether there are standards help us to know when should it be done.

Methods: The aim of this study is to spot light on (t.TG) IgA in celiac disease.

It conducted at the University Children's Hospital in Damascus from 1 January 2008 till 31 December 2011, we made (t.TG) IgA for 90 children with celiac disease (54 males and 36 females), their ages were from 9 to 36 months.

Results: Trans glutaminase antibodies were positive in 71 cases (79%), and negative in 19 cases, and we noted that the prevalence of negative cases was higher in females, IgA selective deficiency was diagnosed in 19 children (21%), which is higher than the world ratios mentioned to repeat this disorder among patients with celiac disease (2%), (p-value=0.0005), and we found that the IgA values were always low (100%) in the negative trans glutaminase sample, and we have seen valuable elevated in liver enzymes 2-3 times than normal (unexplained).

Also we have seen increased incidence of mixed and macrocytic anemia (low B9, low B12), (p-value=0.0043) in negative trans glutaminase cases.

Conclusions: The trans glutaminase based on the levels of serum IgA immunoglobin, there is no need to caliber the trans glutaminase if there was IgA selective deficiency, and we have seen that if the celiac patient is female with anemia (B12 malabsorption), and elevated in liver enzymes 2-3 times than normal, then the trans glutaminase mostly will by negative, and perhaps this could be an address for further research studies.