Hyaluronan and RHAMM in Wound Repair and the “Cancerization” of Stromal Tissues
Joint Authors
Turley, Eva A.
McCarthy, James B.
Tolg, Cornelia
Yazdani, Arjang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Tumors and wounds share many similarities including loss of tissue architecture, cell polarity and cell differentiation, aberrant extracellular matrix (ECM) remodeling (Ballard et al., 2006) increased inflammation, angiogenesis, and elevated cell migration and proliferation.
Whereas these changes are transient in repairing wounds, tumors do not regain tissue architecture but rather their continued progression is fueled in part by loss of normal tissue structure.
As a result tumors are often described as wounds that do not heal.
The ECM component hyaluronan (HA) and its receptor RHAMM have both been implicated in wound repair and tumor progression.
This review highlights the similarities and differences in their roles during these processes and proposes that RHAMM-regulated wound repair functions may contribute to “cancerization” of the tumor microenvironment.
American Psychological Association (APA)
Tolg, Cornelia& McCarthy, James B.& Yazdani, Arjang& Turley, Eva A.. 2014. Hyaluronan and RHAMM in Wound Repair and the “Cancerization” of Stromal Tissues. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-446631
Modern Language Association (MLA)
Tolg, Cornelia…[et al.]. Hyaluronan and RHAMM in Wound Repair and the “Cancerization” of Stromal Tissues. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-446631
American Medical Association (AMA)
Tolg, Cornelia& McCarthy, James B.& Yazdani, Arjang& Turley, Eva A.. Hyaluronan and RHAMM in Wound Repair and the “Cancerization” of Stromal Tissues. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-446631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446631