Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis
Joint Authors
Bunderson-Schelvan, Melisa
Holian, Andrij
Biswas, Rupa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pulmonary fibrosis is a progressive, disabling disease with mortality rates that appear to be increasing in the western population, including the USA.
There are over 140 known causes of pulmonary fibrosis as well as many unknown causes.
Treatment options for this disease are limited due to poor understanding of the molecular mechanisms of the disease progression.
However, recent progress in inflammasome research has greatly contributed to our understanding of its role in inflammation and fibrosis development.
The inflammasome is a multiprotein complex that is an important component of both the innate and adaptive immune systems.
Activation of proinflammatory cytokines following inflammasome assembly, such as IL-1β and IL-18, has been associated with development of PF.
In addition, components of the inflammasome complex itself, such as the adaptor protein ASC have been associated with PF development.
Recent evidence suggesting that the fibrotic process can be reversed via blockade of pathways associated with inflammasome activity may provide hope for future drug strategies.
In this paper we will give an introduction to pulmonary fibrosis and its known causes.
In addition, we will discuss the importance of the inflammasome in the development of pulmonary fibrosis as well as discuss potential future treatment options.
American Psychological Association (APA)
Biswas, Rupa& Bunderson-Schelvan, Melisa& Holian, Andrij. 2011. Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis. Pulmonary Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-446790
Modern Language Association (MLA)
Biswas, Rupa…[et al.]. Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis. Pulmonary Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-446790
American Medical Association (AMA)
Biswas, Rupa& Bunderson-Schelvan, Melisa& Holian, Andrij. Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis. Pulmonary Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-446790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446790