![](/images/graphics-bg.png)
Role of Hypertension in Aggravating Aβ Neuropathology of AD Type and Tau-Mediated Motor Impairment
Joint Authors
Humala, N.
Díaz-Ruiz, C.
Qian, X.
Pasinetti, Giulio Maria
Wang, Jun
Ksiezak-Reding, H.
Martínez-Martín, P.
Thomas, S.
Ho, Lap
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Epidemiological evidence suggests that hypertension may accelerate the onset and progression of Alzheimer's disease (AD).
In this study, we explored the role of hypertension in the neurodegenerative changes associated with Aβ and tau aggregation.
We induced hypertension in APPswe Tg2576 and P301L-tauTg mouse models.
In Tg2576 mice, experimental hypertension was associated with a significant increase of the accumulation of Amyloid-β (Aβ) peptides in brain tissue and a significant reduction of Aβ peptides in serum (P<.05).
These results indicate that hypertension may promote AD-type Aβ neuropathology in Tg2576.
In P301L-tauTg mice we found that the presence of hypertension was significantly associated with aggravated motor function assessed by hindlimb extension test (P=.01).
These results suggest that hypertension may play a role in accelerating the progression of motor dysfunction associated with tau-related alterations.
Our studies suggest that the management of blood pressure (BP) may alleviate AD-type Aβ neuropathology and neurological disorders associated with abnormal tau metabolism.
American Psychological Association (APA)
Díaz-Ruiz, C.& Wang, Jun& Ksiezak-Reding, H.& Ho, Lap& Qian, X.& Humala, N.…[et al.]. 2009. Role of Hypertension in Aggravating Aβ Neuropathology of AD Type and Tau-Mediated Motor Impairment. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-446954
Modern Language Association (MLA)
Díaz-Ruiz, C.…[et al.]. Role of Hypertension in Aggravating Aβ Neuropathology of AD Type and Tau-Mediated Motor Impairment. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-446954
American Medical Association (AMA)
Díaz-Ruiz, C.& Wang, Jun& Ksiezak-Reding, H.& Ho, Lap& Qian, X.& Humala, N.…[et al.]. Role of Hypertension in Aggravating Aβ Neuropathology of AD Type and Tau-Mediated Motor Impairment. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-446954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446954