Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease
Joint Authors
Marschner, Kira
Nees, Josef A.
Donix, Katharina L.
Werner, Annett
Gerner, Antje
Scharf, Maria
Meyer, Shirin
Holthoff, Vjera A.
Von Kummer, Rüdiger
Sauer, Cathrin
Donix, Markus
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cardiovascular risk factors influence onset and progression of Alzheimer’s disease.
Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage.
In patients with Alzheimer’s disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory.
We wanted to investigate whether this regional cortical thinning would be modulated by cardiovascular risk factors.
We utilized high-resolution magnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer’s disease.
Cardiovascular risk was assessed using a sex-specific multivariable risk score.
Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2/3/dentate gyrus area but not other hippocampal and medial temporal subregions.
APOE genotype, a family history of Alzheimer’s disease, and age did not influence cortical thickness.
Alzheimer’s disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable.
This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer’s disease.
American Psychological Association (APA)
Donix, Markus& Scharf, Maria& Marschner, Kira& Werner, Annett& Sauer, Cathrin& Gerner, Antje…[et al.]. 2013. Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447024
Modern Language Association (MLA)
Donix, Markus…[et al.]. Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447024
American Medical Association (AMA)
Donix, Markus& Scharf, Maria& Marschner, Kira& Werner, Annett& Sauer, Cathrin& Gerner, Antje…[et al.]. Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447024