Self-Nanoemulsifying Powder of Isotretinoin : Preparation and Characterization
Joint Authors
Dave, Shruti
Patel, Chhaganbhai N.
Chavada, Gordhan
Chavda, Hitesh
Patel, Ankini
Patel, Jaimeen
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Materials Science , Minerals
Abstract EN
In the present investigation an attempt was made to enhance the solubility and dissolution of poorly soluble drug, isotretinoin, by formulating self-nanoemulsifying drug delivery system (SNEDDS).
Liquid SNEDDSs were prepared using Transcutol P as oil, Tween 80 as surfactant, and PEG 400 as cosurfactant.
Pseudoternary phase diagrams were constructed to identify the efficient self-nanoemulsification region.
The formulation with 40% oil (Transcutol P) and 60% surfactant: cosurfactant (Tween 80: PEG 400) ratio of 1 : 1 was optimized based on evaluation parameters for droplet size analysis, self-emulsification capacity, zeta potential, and in vitro drug release performance.
The optimized system contains mean droplet size of 36.60 nm and zeta potential (ζ) −26.73 mV.
The optimized formulation A1 was adsorbed onto Fujicalin to produce solid SNEDDS, which exhibited good flow properties and preserved the self-emulsification properties of liquid SNEDDS.
The differential scanning calorimetry, FT-IR studies of solid SNEDDS revealed transformation of isotretinoin into molecularly dissolved state in the liquid SNEDDS.
In vitro dissolution profiles showed that dissolution rate of ISN from solid SNEDDS was significantly greater as compared to pure drug.
American Psychological Association (APA)
Chavda, Hitesh& Patel, Jaimeen& Chavada, Gordhan& Dave, Shruti& Patel, Ankini& Patel, Chhaganbhai N.. 2013. Self-Nanoemulsifying Powder of Isotretinoin : Preparation and Characterization. Journal of Powder Technology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-447078
Modern Language Association (MLA)
Chavda, Hitesh…[et al.]. Self-Nanoemulsifying Powder of Isotretinoin : Preparation and Characterization. Journal of Powder Technology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-447078
American Medical Association (AMA)
Chavda, Hitesh& Patel, Jaimeen& Chavada, Gordhan& Dave, Shruti& Patel, Ankini& Patel, Chhaganbhai N.. Self-Nanoemulsifying Powder of Isotretinoin : Preparation and Characterization. Journal of Powder Technology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-447078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447078