Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo
Joint Authors
Guo, Shaoying
Qin, Jianguo
Zhong, Xiang-Gen
Cheng, Fafeng
Sun, Xiaoguang
Wang, Xueqian
Song, Wenting
Lu, Yi
Wang, Qingguo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We investigated the effects of baicalin on an ischemia-reperfusion-induced brain injury model in rats and its antioxidative activities in vitro and in vivo.
An ischemia-reperfusion injury of the brain via a middle cerebral artery occlusion (MCAO) was induced in rats.
Baicalin was injected at different time points (0, 2, 4, and 6 h) after the MCAO was induced.
Baicalin can improve neurological function and significantly decrease brain infarction within a time window of 4 h.
Moreover, baicalin was able to reduce cell apoptosis and had the strong antioxidative effect of reducing reactive oxygen species production and malondialdehyde generation.
In contrast, baicalin interfered with superoxide dismutase and nicotinamide adenine dinucleotide 2′-phosphate oxidase activities.
Moreover, baicalin also exhibited strong neuroprotective effects against H2O2-mediated injury and improved the SOD activity of neurons.
Furthermore, baicalin demonstrated good scavenging of hydroxyl radicals, superoxide anions, and DPPH radicals and exerted an additional effect of inhibiting xanthine oxidase.
Baicalin showed beneficial effects against MCAO-induced injury within a 4 h time window, and its antioxidative effects both in vitro and in vivo may partly elucidate its mechanism of action.
American Psychological Association (APA)
Cheng, Fafeng& Lu, Yi& Zhong, Xiang-Gen& Song, Wenting& Wang, Xueqian& Sun, Xiaoguang…[et al.]. 2013. Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-447225
Modern Language Association (MLA)
Cheng, Fafeng…[et al.]. Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-447225
American Medical Association (AMA)
Cheng, Fafeng& Lu, Yi& Zhong, Xiang-Gen& Song, Wenting& Wang, Xueqian& Sun, Xiaoguang…[et al.]. Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-447225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447225