Musculoskeletal Regenerative Engineering : Biomaterials, Structures, and Small Molecules
Joint Authors
James, Roshan
Laurencin, Cato T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Musculoskeletal tissues are critical to the normal functioning of an individual and following damage or degeneration they show extremely limited endogenous regenerative capacity.
The future of regenerative medicine is the combination of advanced biomaterials, structures, and cues to re-engineer/guide stem cells to yield the desired organ cells and tissues.
Tissue engineering strategies were ideally suited to repair damaged tissues; however, the substitution and regeneration of large tissue volumes and multi-level tissues such as complex organ systems integrated into a single phase require more than optimal combinations of biomaterials and biologics.
We highlight bioinspired advancements leading to novel regenerative scaffolds especially for musculoskeletal tissue repair and regeneration.
Tissue and organ regeneration relies on the spatial and temporal control of biophysical and biochemical cues, including soluble molecules, cell-cell contacts, cell-extracellular matrix contacts, and physical forces.
Strategies that recapitulate the complexity of the local microenvironment of the tissue and the stem cell niche play a crucial role in regulating cell self-renewal and differentiation.
Biomaterials and scaffolds based on biomimicry of the native tissue will enable convergence of the advances in materials science, the advances in stem cell science, and our understanding of developmental biology.
American Psychological Association (APA)
James, Roshan& Laurencin, Cato T.. 2014. Musculoskeletal Regenerative Engineering : Biomaterials, Structures, and Small Molecules. Advances in Biomaterials،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-447382
Modern Language Association (MLA)
James, Roshan& Laurencin, Cato T.. Musculoskeletal Regenerative Engineering : Biomaterials, Structures, and Small Molecules. Advances in Biomaterials No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-447382
American Medical Association (AMA)
James, Roshan& Laurencin, Cato T.. Musculoskeletal Regenerative Engineering : Biomaterials, Structures, and Small Molecules. Advances in Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-447382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447382