Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections
Joint Authors
Caro-Hernández, Paola
Haag, Andreas F.
Ferguson, Gail P.
Arnold, Markus F. F.
Myka, Kamila K.
Source
International Journal of Microbiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis.
Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans.
Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system.
Sugar-modified components in the Brucella cell envelope play an important role in their host interaction.
Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system.
Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell.
This paper will focus on the role of LPS and cyclic β-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.
American Psychological Association (APA)
Haag, Andreas F.& Myka, Kamila K.& Arnold, Markus F. F.& Caro-Hernández, Paola& Ferguson, Gail P.. 2010. Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections. International Journal of Microbiology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-447500
Modern Language Association (MLA)
Haag, Andreas F.…[et al.]. Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections. International Journal of Microbiology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-447500
American Medical Association (AMA)
Haag, Andreas F.& Myka, Kamila K.& Arnold, Markus F. F.& Caro-Hernández, Paola& Ferguson, Gail P.. Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections. International Journal of Microbiology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-447500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447500