The Effect of Citrus Peel Extracts on Cytokines Levels and T Regulatory Cells in Acute Liver Injury
Joint Authors
Pantsulaia, Ia
Pantsulaia, Nato
Iobadze, Manana
Chikovani, Tinatin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
T cell-mediated immune responses contribute to the hepatocellular injury during autoimmune hepatitis, viral infection, and hepatotoxins.
Pharmacological compounds regulating immune responses are suitable candidates for prevention/treatment of this pathology.
Therefore, the main aim of this study was to define the effects of antioxidant, anti-inflammatory mixture of citrus peel extract (CPE) on the immune-mediated liver injury.
Methods.
The influence of CPE on liver injury was determined by the activity of transaminases in plasma and the histological changes.
Anti-inflammatory and antioxidant effects were studied by measuring frequency of T regulatory cells (Tregs), cytokines (TNF-α, IL-10, and IFN-γ), and nitric oxide levels.
Results.
The CPE application notably prevents development of liver injury through decreasing levels of both cytokines (TNF-alpha, INF) and regulatory T cells and increasing levels of IL-10.
CPE injection also diminished the serum NO, which in turn resulted in evident reduction of the liver damage.
Conclusion.
Our findings represent the primary preclinical data indicating that the CPE in vivo could ameliorate Con A induced hepatitis.
The low dose of CPE most likely can be used for the treatment of the T cell-mediated liver injury as in autoimmune hepatitis, alcoholic hepatitis, and chronic viral hepatitis.
American Psychological Association (APA)
Pantsulaia, Ia& Iobadze, Manana& Pantsulaia, Nato& Chikovani, Tinatin. 2014. The Effect of Citrus Peel Extracts on Cytokines Levels and T Regulatory Cells in Acute Liver Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-447845
Modern Language Association (MLA)
Pantsulaia, Ia…[et al.]. The Effect of Citrus Peel Extracts on Cytokines Levels and T Regulatory Cells in Acute Liver Injury. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-447845
American Medical Association (AMA)
Pantsulaia, Ia& Iobadze, Manana& Pantsulaia, Nato& Chikovani, Tinatin. The Effect of Citrus Peel Extracts on Cytokines Levels and T Regulatory Cells in Acute Liver Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-447845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447845