Schizophrenia : A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-37, 37 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
37
Main Subjects
Abstract EN
Many genes have been implicated in schizophrenia as have viral prenatal or adult infections and toxoplasmosis or Lyme disease.
Several autoantigens also target key pathology-related proteins.
These factors are interrelated.
Susceptibility genes encode for proteins homologous to those of the pathogens while the autoantigens are homologous to pathogens' proteins, suggesting that the risk-promoting effects of genes and risk factors are conditional upon each other, and dependent upon protein matching between pathogen and susceptibility gene products.
Pathogens' proteins may act as dummy ligands, decoy receptors, or via interactome interference.
Many such proteins are immunogenic suggesting that antibody mediated knockdown of multiple schizophrenia gene products could contribute to the disease, explaining the immune activation in the brain and lymphocytes in schizophrenia, and the preponderance of immune-related gene variants in the schizophrenia genome.
Schizophrenia may thus be a “pathogenetic” autoimmune disorder, caused by pathogens, genes, and the immune system acting together, and perhaps preventable by pathogen elimination, or curable by the removal of culpable antibodies and antigens.
American Psychological Association (APA)
Carter, Chris. 2011. Schizophrenia : A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes. Journal of Pathogens،Vol. 2011, no. 2011, pp.1-37.
https://search.emarefa.net/detail/BIM-447885
Modern Language Association (MLA)
Carter, Chris. Schizophrenia : A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes. Journal of Pathogens No. 2011 (2011), pp.1-37.
https://search.emarefa.net/detail/BIM-447885
American Medical Association (AMA)
Carter, Chris. Schizophrenia : A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes. Journal of Pathogens. 2011. Vol. 2011, no. 2011, pp.1-37.
https://search.emarefa.net/detail/BIM-447885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447885