Glycogen Synthase Kinase-3β : A Mediator of Inflammation in Alzheimer's Disease?
Joint Authors
Malm, Tarja
Koistinaho, Jari
Goldsteins, Gundars
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Proliferation and activation of microglial cells is a neuropathological characteristic of brain injury and neurodegeneration, including Alzheimer's disease.
Microglia act as the first and main form of immune defense in the nervous system.
While the primary function of microglia is to survey and maintain the cellular environment optimal for neurons in the brain parenchyma by actively scavenging the brain for damaged brain cells and foreign proteins or particles, sustained activation of microglia may result in high production of proinflammatory mediators that disturb normal brain functions and even cause neuronal injury.
Glycogen synthase kinase-3β has been recently identified as a major regulator of immune system and mediates inflammatory responses in microglia.
Glycogen synthase kinase-3β has been extensively investigated in connection to tau and amyloid β toxicity, whereas reports on the role of this enzyme in neuroinflammation in Alzheimer's disease are negligible.
Here we review and discuss the role of glycogen synthase-3β in immune cells in the context of Alzheimer's disease pathology.
American Psychological Association (APA)
Koistinaho, Jari& Malm, Tarja& Goldsteins, Gundars. 2011. Glycogen Synthase Kinase-3β : A Mediator of Inflammation in Alzheimer's Disease?. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-448034
Modern Language Association (MLA)
Koistinaho, Jari…[et al.]. Glycogen Synthase Kinase-3β : A Mediator of Inflammation in Alzheimer's Disease?. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-448034
American Medical Association (AMA)
Koistinaho, Jari& Malm, Tarja& Goldsteins, Gundars. Glycogen Synthase Kinase-3β : A Mediator of Inflammation in Alzheimer's Disease?. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-448034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448034